Early trajectories of skin thickening are associated with. The complications of severe digital vasculopathy often require hospitalbased management with intravenous therapies and surgery. Levels of circulating endothelial progenitor cells in. Universite paris descartes, rhumatologie a, hopital cochin aphp, paris, france musculoskeletal involvement is common in patients with systemic sclerosis and is a major cause of disability. Association of the tnfaip3 rs5029939 variant with systemic. Preclinical studies suggest a role for lysophosphatidic acid lpa in the pathogenesis of systemic sclerosis ssc. Predictors of hypogammaglobulinemia during rituximab maintenance therapy in rheumatoid arthritis. Ultrasound us is sensitive for detection of power doppler pd vascularization. Randomised controlled trials in systemic sclerosis.
2 cardiovascular risk factors cardiac markers in rheumatoid arthritis independently of traditional inflammation and disease activity are associated with high circulating. Comprised of the authoritative work of international experts, this fullyupdated second edition of scleroderma builds upon the wellregarded approach in the first edition to provide integrated, concis. He is the head of a research group working on the cardiovascular clinical aspects of systemic sclerosis and on pathogenesis, through genetic and cellular biology approaches inserm u1016, cochin institute, team chronic inflammation and. Hoffmannvold am, allanore y, alves m, graf n, airo p, ananyeva l, czirjak l, guiducci s, hachulla e, li m, mihai c, sfikakis p, valentini g, kowalbielecka o, distler o. Methods 20 patients with ssc with refractory polyarthritis and seven with refractory myopathy from the eustar eular scleroderma trials and research network were included. Levels of circulating endothelial progenitor cells in systemic sclerosis y. Our aim was to explore the associations between a set of complementary circulating angiogenic markers. Circulating endothelial progenitor cells in systemic. The main mechanism of crystalinduced inflammation is interleukin1 production by activation of the inflammasome.
Aug 12, 2019 systemic sclerosis c is a heterogeneous connective tissue disease that is typically subdivided into limited cutaneous c lcc and diffuse cutaneous c dcc depending on the extent of skin involvement. Primary heart involvement in systemic sclerosis authors. Outcomes of patients with systemic sclerosisassociated. Correspondence to professor yannick allanore, service rhumatologie a, hopital cochin, 27 rue du faubourg st jacques, paris 75014, france. Progressive lung fibrosis in patients with systemic.
Primary heart involvement in systemic sclerosis bentham science. Nov 15, 2012 nonbrucellar and nontuberculous infectious sacroiliitis isi is a rare disease, with misleading clinical signs that delay diagnosis. Yannick allanore hashad consultancy relationship andor has received research funding in relationship with the treatment of systemic sclerosis from actelion, bayer, biogen idec, bristolmyers squibb, genentechroche, inventiva, medac, pfizer, sanofigenzyme, servier and ucb. Christopher p denton, oliver distler, yannick allanore, daniel e furst, armando gabrielli, maureen mayes, jacob m van laar, james r seibold, laszlo czirjak, virginia steen, murat inanc, otylia kowal. Comprised of the authoritative work of international experts, this fullyupdated second edition of scleroderma builds upon the wellregarded approach in the first edition to provide integrated, concise, and uptodate synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis scleroderma. Our aim was to evaluate the effects of estrogens in the development of experimental dermal fibrosis, in the mouse models of bleomycininduced dermal fibrosis and tight skin tsk1 mice, and on the activation of dermal. Pr yannick allanore, rhumatologie, aphp cochin, paris dr jerome avouac, rhumatologie, aphp cochin, paris dr brigitte badermeunier, pediatrie, aphp necker, paris dr alexandre belot, pediatrie, chu lyon dr alice berezne, medecine interne, ch annecy dr annesophie bouthors, anesthesie, chu lille. This retrospective study included all isi cases diagnosed between 1995 and 2011 in eight french rheumatology departments. Our aim was to describe the clinical, bacteriological, and radiological characteristics. Lysophosphatidic acid receptor 1 antagonist sar100842 for.
Given that familial pulmonary fibrosis fpf and raild frequently share the usual pattern of interstitial pneumonia and common environmental risk factors, we hypothesised that the two diseases might share. Francesco del galdo, collette hartley, yannick allanore the heterogeneity in the natural history of systemic sclerosis is a major issue in both clinical management and trial design and is dictated by the complex and multifactorial pathogenesis of the disease. Professor allanore is the head of a research group working on the cardiovascular aspects of systemic sclerosis and other chronic inflammatory rheumatic diseases through clinical research programs and basic research ones, including genetic and. To assess dermal expression and fibroblast production of fibrillin1 fbn1 in ssc. Randomised, placebocontrolled study in patients with ssc to assess the effect of sildenafil 20 mg or placebo. Jerome avouac, georges uzan, fabrice juin, andre kahan, catherine boileau and yannick allanore. Shared genetic predisposition in rheumatoid arthritisinterstitial lung disease and familial pulmonary fibrosis pierreantoine juge1,2,51, raphael borie2,3,4,51, caroline kannengiesser2,5,6,51. He is the head of a research group working on the cardiovascular clinical aspects of systemic sclerosis and on pathogenesis, through genetic and cellular biology approaches inserm u1016, cochin institute, team chronic inflammation and autoimmunity, head dr g. Comprised of the authoritative work of international experts, this fullyupdated second edition of scleroderma builds upon the wellregarded approach in the first edition to provide integrated, concise, and uptodate synthesis of current concepts of pathogenesis and modern approaches to management. We undertook this study to assess sar100842, a potent selective oral antagonist of the lpa 1 receptor, for safety, biomarkers, and clinical efficacy in patients with diffuse cutaneous ssc dcssc methods. Phosphodiesterase5 inhibitors for the treatment of secondary. Denton4 microcirculation impairment and related vasculopathy are hallmarks of systemic sclerosis ssc. To demonstrate the equivalent efficacy and compare the safety and immunogenicity of an etanercept biosimilar, gp2015, with reference etanercept etn in patients with moderatetosevere, active rheumatoid arthritis ra, characterised by an inadequate response to synthetic or biologic diseasemodifying antirheumatic drugs dmards. Progressive lung fibrosis in patients with systemic sclerosis.
Digital vasculopathy in systemic sclerosis ssc consists of a spectrum of raynauds phenomenon rp, digital ulcers dus, critical digital ischaemia and escalation to gangrene. Yannick allanore, md, phd christophe meune, md, phd please address correspondence and reprint requests to. We investigated the number of circulating epcs using recent recommendations and we quantified their late outgrowth in patients with ssc and healthy controls. Polymorphisms in the genes encoding interleukin 4 il4, interleukin il, and their corresponding receptors have been associated with multiple immunemediated diseases.
Efficacy of sildenafil on ischaemic digital ulcer healing. Update on musculoskeletal involvement in systemic sclerosis. Yannick allanore got a professor of rheumatology position at the paris descartes university in paris in 2008. Phenotypes determined by cluster analysis and their survival. In vivo analysis of microfibrillar network was performed using em from affected and unaffected skin biopsy specimens of dcssc patients n 5 compared with healthy controls n 2.
Predictors of hypogammaglobulinemia during rituximab. This sex bias raises the question on the role female hormones could play in the development of. Update on musculoskeletal involvement in systemic sclerosis pr yannick allanore. Comprised of the authoritative work of international experts, this fullyupdated second edition of scleroderma builds upon the wellregarded approach in the first edition to provide integrated, concise, and uptodate synthesis of current concepts. Systemic sclerosis ssc is a connective tissue disease characterized by early generalized microangiopathy. View pdf primeboost vaccination strategy enhances immunogenicity compared to single pneumococcal conjugate vaccination in patients receiving conventional dmards, to some extent in abatacept but not in rituximabtreated patients. Sep 17, 20 gout is a common arthritis that occurs particularly in patients who frequently have associated comorbidities that limit the use of conventional therapies. Yannick allanore,1 marco matuccicerinic,2 oliver distler3 to cite. Systemic sclerosis ssc is associated with an increased risk of osteoporosis and fractures. Yannick allanore, md, phd please address correspondence and reprint requests to. To assess the effect of sildenafil, a phosphodiesterase type 5 inhibitor, on digital ulcer du healing in systemic sclerosis ssc. Yannick allanore is professor of rheumatology at the paris descartes university in paris since 2008. The objective of this metaanalysis was to determine the efficacy of pde5 inhibitors on raynauds condition score rcs and frequency and duration of. To date, the etiology of bone loss in ssc is unclear.
This primeview summarizes the mechanisms underlying. However, these antibodies have also been detected in patients with other types of chronic inflammatory. Elisabeth palazzo1, olivier meyer1, pascal richette2, thomas bardin2, yannick allanore4, frederic liote2, maxime dougados3 and philippe dieude1 abstract introduction. Objective to evaluate the safety and effectiveness of tocilizumab and abatacept in systemic sclerosis sscpolyarthritis or sscmyopathy. From pathogenesis to comprehensive management serves as an essential, allinclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients. Although the prognosis of the disease largely depends on. Yannick allanore archives hopital cochin pole osteo. Despite its high prevalence and mortality, little is known about the pathogenesis of rheumatoid arthritisassociated interstitial lung disease raild. Estrogens counteract the profibrotic effects of tgf. Introduction systemic sclerosis sscrelated pulmonary arterial hypertension pah has emerged as a major mortality prognostic factor. Yannick allanore rheumatology a dpt cochin hospital paris.
Objective to explore the genetic bases of sscpah, we combined direct sequencing and genotyping of. Systemic sclerosis is an autoimmune disease characterized by vasculopathyinduced fibrosis of the skin and organs that can be lifethreatening. Yannick allanore,1 on behalf of eustar eular scleroderma trials and research group for numbered af. Neoangiogenesis is a crucial event to promote the development of the hyperplasic proliferative pathologic synovium in rheumatoid arthritis ra. Dipeptidylpeptidase 4 as a marker of activated fibroblasts and a potential target for the treatment of fibrosis in systemic sclerosis alina soare, hermina a. Ladner gabriele valentini, douglas veale, madelon vonk, ulrich a. Clinical characteristics and predictors of gangrene in. Review primary myocardial involvement in systemic sclerosis.
Revue du rhumatisme monographies poumon et rhumatismes. Isi was diagnosed if sacroiliitis was confirmed bacteriologically or, in the absence of pathogenic agents, if clinical, biological, and radiological data was compatible with this diagnosis and evolution was favourable under antibiotic therapy. Most observations are based on isolated case reports or small case series. Boleto g, avouac j, wipff j, forien m, dougados m, roux c, kahan a, dieude p, allanore y.
Update of eular recommendations for the treatment of. Introduction recent controlled trials have assessed the efficacy of phospodiesterase5 pde5 inhibitors in secondary raynauds phenomenon rp. Accepted 20 april 2010 suggesting that the pathological variants may confer. Research article open access efficacy of anakinra in gouty. Gout is a common arthritis that occurs particularly in patients who frequently have associated comorbidities that limit the use of conventional therapies. Yannick allanore rheumatology a dpt cochin hospital paris, france. Given that familial pulmonary fibrosis fpf and raild frequently share the usual pattern of interstitial pneumonia and common environmental risk factors, we hypothesised that the two diseases might share additional risk factors, including. Acreular classification criteria for sclerosis ssc. We aimed to evaluate the efficacy and tolerance of anakinra in gouty patients. Our aim was to describe the clinical, bacteriological, and radiological characteristics of isi, as well as the evolution of these arthritis cases under treatment. However, the conclusions are conflicting, and whether these drugs are effective remains unclear.
This sex bias raises the question on the role female hormones could play in the development of fibrosis, which is largely unknown. The data that support the findings of this study are available on separate scientific request contact prof. Anticyclic citrullinated peptide antibodies anticcp are considered specific markers of rheumatoid arthritis ra and have been included in the revised classification criteria for ra diagnosis. Zurich open repository and archive university of zurich main library strickhofstrasse 39 ch8057 zurich.
Concise report outcomes of patients with systemic sclerosis. Nonbrucellar and nontuberculous infectious sacroiliitis isi is a rare disease, with misleading clinical signs that delay diagnosis. Eric hachulla, department of internal medicine, university of lille, lille, france. Andre kahan, yannick allanore, and catherine cormier abstract. Shared genetic predisposition in rheumatoid arthritis. Matei, clara dees, simon rauber, thomas wohlfahrt, chihwei chen, ingo ludolph. Our aim was to validate these previous observations in patients with systemic sclerosis ssc and scrutinize. Yannick allanore,1 oliver distler,2 alexandre jagerschmidt,3 stephane illiano,3 laetitia ledein,3 eric boitier,4 inoncent agueusop,5 christopher p. A vascular perspective for inflammatory rheumatic disorders.
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